The CIRCA-DOSE trial


The pivotal CIRCA-DOSE study was a randomized study that examined the AF burden in detail and changed how we conceptualise study endpoints when it published in Circulation back in 2019. Dr Dhiraj Gupta (Liverpool, UK) meets with the principal investigator of the study, Dr Jason Andrade (Vancouver, CA), who presents the data behind the original CIRCA-DOSE study and discusses the results from the recent secondary analysis examining the clinical definition of AF, which has recently been published in JAMA Open. They close by discussing how this research might influence clinical practice going forwards.

Prognosis of iLBBB

In this video presentation and discussion, Prof Dhiraj Gupta (Liverpool Heart and Chest Hospital) meets with senior author, Prof Francisco Leyva (Queen Elizabeth Hospital, UK) to review the results of his retrospective, real-world study that aims to answer the common and clinically important question surrounding how to treat patients with an incidental LBBB (iLBBB), and how imaging can be used to support detection. The results showed that patients with iLBBB should be assessed using cardiac MRI as a tool.

References:
1. Zegard A, Okafor O, Bono J, et al. Prognosis of incidental left branch block. Europace 2020;22:956-963.